Welcome to International Institute of Translational Medicine
The main aim of the institute is to conduct basic, industrial and experimental development research, as well as to widely disseminate the results of such activities through teaching, publication or knowledge transfer.
OUR GOALS
Conducting independent and continuous research and development works enables the achievement of the assumed goals through:
01
Publishing research results in prestigious scientific journals
02
Publishing scientific achievements in the international arena
03
Popularization of science by organizing lectures, seminars, symposia, conferences and training
04
Implementation of research projects and research tasks from domestic and foreign funds, in particular in the form of research grants
05
Establishing international relations and creating consortia with other research groups
06
Cooperation with government administration and local government institutions
„Science determines development”
We adhere to the principle that “science determines development”, and thanks to this, through a number of innovative molecular and biotechnological solutions developed by our team, we want to develop advanced therapeutic strategies targeted at both small and large animals. The International Institute of Translational Medicine is synonymous with interdisciplinarity, which allows the development of advanced, cross-disciplinary biomedical solutions based on modern therapeutic strategies using stem cells, implantable materials or advanced molecular diagnostics.
The MIMT team was established in order to develop therapies in the field of theranostics, regenerative medicine and translational medicine, so that the scientific results developed by our team serve the treatment of both animals and humans in the future.
We have developed several proprietary regenerative therapies to improve animal welfare around the world.
BOARD OF DIRECTORS
Mgr Inż. Malwina Mularczyk
PhD student at the University of Life Sciences in Wrocław in the field of biological sciences, specializing in industrial biotechnology, mainly in the use of bioactive ingredients for the production of feed additives. She cooperated with the Wrocław Technology Park, where she belonged to an international scientific consortium dealing with the commercialization of biomarkers (BIC, Interreg Baltic Sea). Assistant at the International Institute of Translational Medicine, responsible for the development of liposomal / micellar forms of active substances for the development of feed additives. He specializes in industrial biotechnology, with particular emphasis on the development of innovative horse feed additives, mainly based on metabolites of probiotic bacteria, as well as obtaining and purifying carotenoids with increased antioxidant activity from yeast cells. She has developed the formulation and production technology of two commercially available probiotic products for horses.
Prof. dr hab. Krzysztof Marycz
GENERAL DIRECTOR OF RESEARCH DEVELOPMENT
General Director of Research & Development at the International Institute of Translational Medicine (MIMT) and Head of Department of Experimental Biology at UPWr. Visiting Professor at Stanford Medical School (USA), University of California, DAVIS (UC DAVIS) and Justus Liebieg Universitat in Giessen (GER).
Manager of grants funded by NCN, PARP, NCBiR and the American agency Center for Environmental Humanities. Honored by the Rector of UPWr and the Minister of Science of Higher Education for outstanding scientific achievements and for obtaining the degree of full professor before the age of 40. Winner of many awards, distinctions, and scholarships, both domestic and foreign awarded by the President of the Republic of Poland, the Prime Minister, the Minister of Science and Higher Education, the Marshal of the Lower Silesian Voivodeship, the Rector of the UPWr and the Rector of the UKSW.
Owner and co-owner of several biotechnology and HiTech companies. He conducts pioneering scientific research in the areas related to stem cells, bio-intelligent implant materials, and bio-drugs. Author of over 220 original research papers from the Philadelphia list, total IF = 820 and index H = 32. Author of 5 patents, two of which have been commercialized and are currently implemented in medical practice. In 2020, appointed by the Minister of Health to the Scientific Council of the National Medicines Institute (NIL).
SCIENTIFIC COUNCIL
Dr Anna Cisło Pakuluk
DR N. FARM. ANNA KOWALCZUK
Dr hab. inż.
Izabela Michalak Prof. PWr
Prof. nadzw. dr hab.
Rafał Wiglusz
STRATEGIC PARTNERS
PROF. DR MICHAEL RÖCKEN
PROF. DR JEAN-MARIE NEDELEC
RESEARCH STAFF
Dr Lynda Bourebaba
MOLECULAR RESEARCH AND IMPLEMENTATION SPECJALIST
Dr. Lynda Bourebaba – senior specialist in molecular research and implementation at the International Institute of Translational Medicine, assistant professor at the Department of Experimental Biology at the University of Life Sciences in Wrocław. After obtaining a doctoral degree in biological sciences at the University of Bejaia, she expanded her scientific achievements in European centers, including at the foodomics laboratory at the CIAL Institute in Madrid, the Laboratory of Experimental Anticancer Therapy at the Institute of Immunology and Experimental Therapy of the Polish Academy of Sciences in Wrocław and the Department of Experimental Biology at the University of Life Sciences in Wrocław. He specializes in techniques of molecular biology, immunochemistry, cell cultures and methods of obtaining plant bioactive compounds. During her scientific career, she has developed many dietary supplements for animals based on a combination of natural extracts and nutrients, based on extensive experience in the field of obtaining and extracting bioactive compounds from plant materials and algae (antioxidant, anti-inflammatory compounds, phenolic compounds, alkaloids, essential oils) using methods maceration, fractionation, hydrodistillation, extraction and biosorption.
Dr Maria Soltero-Rivera
CLINICAL VETERUNARY ADVISOR
Dr. Maria Soltero – Riviera veterinary dentist and expert in biomedical and molecular research in the International
Institute of Translational Medicine, assistant professor in dentistry and oral surgery at the Faculty of Surgical Sciences and
Radiological Sciences School of Veterinary Medicine, University of California, Davis. He has been actively involved in for 7 years
oral medicine research in dogs and cats. The ongoing research focuses on the characteristics of inflammation and
oral cancer in dogs and cats to develop robust and state-of-the-art methods and / or criteria
diagnostic. Current projects include next-generation metagenomic sequencing for characterization
potential etiologic factors of chronic feline gingivitis and aggressive feline periodontitis, a
also validation of a bacterial and host biomarker for the diagnosis of early periodontitis in dogs. Close
I collaborate with many researchers from UC Davis, UC San Francisco (De Risi Lab), Penn Vet, NC State University and Waltham Pet
Care Science Institute. The research conducted by M. Soltero – Riviera aims to define naturally occurring
animal models of stomatitis and neoplasia, and the improvement of diagnostic capacity for cavity health
the oral cavity of humans and animals to enable early diagnosis, treatment and prevention
Dr Anna Cisło-Pakuluk
DIRECTOR FOR SMALL ANIMALS
A graduate of the Faculty of Veterinary Medicine in Wrocław. He has been dealing with eye diseases of dogs, cats and horses since 2005. During her studies, she completed numerous internships and internships, including as a scholarship holder at the University of Budapest and the University of Ludwik Maximilian in Munich, in one of the best centers of veterinary ophthalmology in Europe under the supervision of prof. H. Gerhards. After an internship at a horse hospital, she gained experience in the field of companion animal diseases in one of the largest clinics in Wrocław. Member of the European Society of Veterinary Ophthalmology, a longtime translator of ophthalmic publications for Elsevier, author of many articles in the trade press. He regularly participates in ESVO and ECVO conventions. He has completed a course in cataract surgery using the phacoemulsification method and cryosurgery. She completed the 1st degree course in ophthalmology in Luxembourg and the 2nd degree course in the field of ophthalmic surgery organized in Toulouse. Since 2016, he has additionally been involved in scientific work in the field of applying the latest achievements in regenerative medicine in the treatment of retinal diseases.
Dr n. wet. Mateusz Hecold
Mateusz Hecold in the years 2004-2017, doctor and academic teacher at the Horse Clinic of the Warsaw University of Life Sciences, assistant professor and head of the Radiological Laboratory at the Department of Surgery, Department of Large Animal Diseases with the Horse Clinic, Faculty of Veterinary Medicine, Warsaw University of Life Sciences. In 2016, he defended his doctoral dissertation on the impact of training on changes in the shape of bones in young half-blooded horses, thus obtaining a doctorate in veterinary sciences. Dr. Hecold holds the titles of a specialist in equine diseases, a specialist in veterinary radiology, a doctor of the Polish Equestrian Federation (PZJ) and a doctor of the International Equestrian Federation (FEI). Since 2016, a caretaker and veterinary consultant in the sports stable of rally horses in the United Arab Emirates.
The fields of hypiatrics, which Dr. n. Vet. Mateusz Hecold deals with orthopedics, regeneration therapies for joints and tendons (IRAP, stem cells, PRP), physical therapy (high-energy laser therapies, shock wave theraphy and sonotherapy).
Lek. wet. Magdalena Kraińska
A graduate of the Faculty of Veterinary Medicine at the University of Life Sciences in Lublin in 2012. PhD student at the First Faculty of Medicine at the Medical University of Warsaw at the Department of General and Transplant Surgery. He consults nephrological and urological patients from all over the country, qualifies and performs hemodialysis procedures in dogs and cats, is a co-creator of a modern dialysis station for animals at the 24-hour Veterinary Clinic “Puławska” in Warsaw. She is a co-author and co-organizer of the first Practical Nephrology Workshops for veterinarians in Poland, lecturer at numerous conferences in Poland and abroad, author of articles published in specialist veterinary press and a member of the European Society of Veterinary Nephrology and Urology (ESVNU). In 2020, she began studying surgery at the European School for Advanced Veterinary Studies (ESAVS) in Luxembourg. She is of particular interest in acute kidney damage, vascular and transplant surgery, and methods of renal replacement therapy. Leader of the “Nefro-Regen” consortium consisting of scientists from the International Institute of Translational Medicine (MIMT), the National Medicines Institute (NIL) and the Central Clinical Hospital of the Ministry of Interior and Administration in Warsaw, whose research was sponsored by the Director of the National Medicines Institute (NIL) in Warsaw.
Lek. wet. Natalia Siwińska
A graduate of the Faculty of Veterinary Medicine at the University of Life Sciences in Wrocław. He has been dealing with horse diseases since graduation, but he has been interested in horses since childhood. She gained her extensive experience in many clinics, both in Poland and abroad. After graduation, she completed an internship at the Equi Vet Serwis Horse Clinic of Dr. Maciej Przewoźny, where she later worked as an independent doctor for over two years. Since 2015, she has been professionally associated with the Department of Internal Medicine of Horses, Dogs and Cats, University of Life Sciences in Wrocław. During her many years of practice, she gained experience in many renowned horse treatment centers, such as TiHO in Germany, VetMedUni in Austria, Animal Health Trust in Great Britain, Clinique vétérinaire équine de Grosbois in France, Weipers Center Equine Hospital in Scotland, Animal Clinic (Equine cardioteam) Ghent University in Belgium.
Her main clinical interests are internal diseases of horses – in particular diseases of the respiratory system, cardiology, diseases of the digestive system, diseases of the urinary system, liver diseases and ultrasound diagnostics of the chest (including heart) and abdominal cavity. Two of these fields of medicine became the subject of her doctoral dissertation, entitled “Diagnosis of early kidney damage in horses using ultrasound and serum and urine biomarkers.” She diagnoses patients with accuracy, according to the “thread to the ball” principle, and cooperation with many centers from abroad allows her to consult her patients with the greatest specialists in the world.
Lek. wet. Katarzyna Hołownia-Olszak
A graduate of the Faculty of Veterinary Medicine at the University of Life Sciences in Wrocław 2016. Since 2019, he has been deepening his knowledge in the field of canine and feline dentistry. She completed a 3-stage educational program “Small Animal Dentistry for Veterinarians”, organized by the Polish Association of Small Animal Veterinarians, as well as courses in the basics of orthodontics, extraction and facial and maxillary surgery of dogs and cats. He is a member of the EVDS. Her main interests are periodontics and diseases of the oral mucosa.
Mgr inż. Justyna Kornicka
A graduate of Molecular Biotechnology and Biocatalysis at the Faculty of Chemistry, Wrocław University of Technology. During her engineering studies, she dealt with the search for an alternative method of fighting pathogens and preventing the formation of bacterial infections and epidemic outbreaks. To this end, it synthesized bacterial serine protease inhibitors as a new therapeutic approach. During her master’s studies, under the supervision of the Director of the National Medicines Institute, she worked on the influence of cannabinoids derived from Cannabis sativa L. in the prevention of insulin resistance and type 2 diabetes. She is a certified specialist in R&D projects. She completed courses in business negotiations, obtaining EU funds and the “Digital Marketing Course” conducted by, among others, Rob Percival. For a year, he has been cooperating with biotechnology companies, the High-tech and IT industry, on obtaining EU funds in prestigious grants and competitions (EU funds, PFR, NCBiR). At the International Institute of Translational Medicine, he continues to study the therapeutic potential of cannabis-derived compounds on ASCs-Adipose-derived stem cells. She is also responsible for the development of innovation, contact with partners and for establishing cooperation.
Mgr Inż. Piotr Rudnicki
Implementation graduate student at the University of Life Sciences in Wrocław in the field of Laboratory Techniques in Biology. Rector’s scholarship holder for outstanding academic results and outstanding scientific achievements. During his first-cycle studies at the Department of Experimental Biology, he participated in research projects on the search for new methods of treating insulin resistance in horses suffering from metabolic syndrome (EMS). Laureate of prestigious scientific competitions, including “Young Minds – Young Minds Project”. At the International Institute of Translational Medicine, he deals with the development of an innovative cyclosporin A (CsA) subdural implant and research on the regenerative properties of CSSCs stem cells isolated from the cornea of dogs.
Our publications
1) Al Naem M., Bourebaba L., Kucharczyk K., Röcken M., Marycz K. 2019. Therapeutic mesenchymal stromal stem cells: Isolation, characterization and role in equine regenerative medicine and metabolic disorders. Stem Cell Rep Rev. Doi: 10.1007/s12015-019-09932-0.
2) Marycz K., Kosarzewska-Szłapka J., Geburek F., Kornicka-Garbowska K. 2019. Systemic Administration of Rejuvenated Adipose-Derived Mesenchymal Stem Cells Improves Liver Metabolism in Equine Metabolic Syndrome (EMS)- New Approach in Veterinary Regenerative Medicine. Stem Cell Rev and Rep. Doi: 10.1007/s12015-019-09913-3
3) Alicka M., Kornicka-Garbowska K., Röcken M., Marycz K. 2019. Inhibition of the Low Molecular Weight Protein Tyrosine Phosphatase (LMPTP) as a Potential Therapeutic Strategy for Hepatic Progenitor Cells Lipotoxicity-Short Communication. Int. J. Mol. Sci. 20(23), 5873. Doi:10.3390/ijms20235873
4) Bourebaba L., Marycz K. 2019. Pathophysiological Implication of Fetuin-A Glycoprotein in the Development of Metabolic Disorders: A Concise Review. J. Clin. Med.8(12), 2033. Doi: 10.3390/jcm8122033
5) Alicka M., Major P., Wysocki M., Marycz K. 2019. Adipose-Derived Mesenchymal Stem Cells Isolated from Patients with Type 2 Diabetes Show Reduced “Stemness” through an Altered Secretome Profile, Impaired Anti-Oxidative Protection, and Mitochondrial Dynamics Deterioration. J. Clin. Med. 8, 765. Doi: 10.3390/jcm8060765.
6) Kornicka-Garbowska K., Geburek F., Röcken M., Marycz K. 2019. Stem Cells in Equine Veterinary Practice—Current Trends, Risks, and Perspectives. J. Clin. Med. 8, 675. Doi: 10.3390/jcm8050675.
7) Kornicka-Garbowska K., Al Naem M., Röcken M., Zmiertka M., Marycz K. 2019. Osteochondritis Dissecans (OCD)-Derived Chondrocytes Display Increased Senescence, Oxidative Stress, Chaperone-Mediated Autophagy and, in Co-Culture with Adipose-Derived Stem Cells (ASCs), Enhanced Expression of MMP-13. J. Clin. Med. 8(3), 328. Doi: 10.3390/jcm8030328
8) Watras A., Wujczyk M., Röcken M., Kucharczyk K., Marycz K., Wiglusz R.J. 2019. Investigation of Pyrophosphates KYP2O7Co-Doped with Lanthanide Ions Useful for Theranostics. Nanomaterials, 9(11), 1597. Doi:10.3390/nano9111597.
9) Bourebaba L., Bedjou F., Röcken M., Marycz K. 2019. Nortropane alkaloids as pharmacological chaperones in the rescue of equine adipose-derived mesenchymal stromal stem cells affected by metabolic syndrome through mitochondrial potentiation, endoplasmic reticulum stress mitigation and insulin resistance alleviation. Stem Cell Res Ther. 10, 178. Doi: 10.1186/s13287-019-1292-z.
RESEARCH FACILITIES
The Institute has specialized laboratories for molecular biology, cell culture as well as microbiological and prototype laboratories. All rooms are equipped with the highest quality equipment, enabling research in the field of biology and biotechnological processes.
ADMINISTRATION
The efficient functioning of the Institute is supervised by specialized administrative staff, which includes: legal counselor, accounting and administrative employee.
