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RESEARCH AND DEVELOPMENT

Science. Technology. Knowledge transfer.

PARTNERSHIP

We are open to cooperation with clinicians as well as scientists and investors focused on regenerative medicine. As part of the Institute’s activities, it is possible to treat both large and small animals in stationary patients using the therapeutic strategies we offer. What distinguishes us is the high therapeutic standards and the quality guarantee of the therapies developed by us. Regenerative therapies developed by MIMT are available to patients only on the recommendation of the treating physician.

In order to establish cooperation, please contact us:

info@mimt.com.pl | +48 505 469 278

 

 

THEY TRUSTED US

 

 

 

 

 

 

 

 

Research supported by several scientific publications

1) Al Naem M., Bourebaba L., Kucharczyk K., Röcken M., Marycz K. 2019. Therapeutic mesenchymal stromal stem cells: Isolation, characterization and role in equine regenerative medicine and metabolic disorders. Stem Cell Rep Rev. Doi: 10.1007/s12015-019-09932-0.

2) Marycz K., Kosarzewska-Szłapka J., Geburek F., Kornicka-Garbowska K. 2019. Systemic Administration of Rejuvenated Adipose-Derived Mesenchymal Stem Cells Improves Liver Metabolism in Equine Metabolic Syndrome (EMS)- New Approach in Veterinary Regenerative Medicine. Stem Cell Rev and Rep. Doi: 10.1007/s12015-019-09913-3

3) Alicka M., Kornicka-Garbowska K., Röcken M., Marycz K. 2019. Inhibition of the Low Molecular Weight Protein Tyrosine Phosphatase (LMPTP) as a Potential Therapeutic Strategy for Hepatic Progenitor Cells Lipotoxicity-Short Communication. Int. J. Mol. Sci. 20(23), 5873. Doi:10.3390/ijms20235873

4) Bourebaba L., Marycz K. 2019. Pathophysiological Implication of Fetuin-A Glycoprotein in the Development of Metabolic Disorders: A Concise Review. J. Clin. Med.8(12), 2033. Doi: 10.3390/jcm8122033

5) Alicka M., Major P., Wysocki M., Marycz K. 2019. Adipose-Derived Mesenchymal Stem Cells Isolated from Patients with Type 2 Diabetes Show Reduced “Stemness” through an Altered Secretome Profile, Impaired Anti-Oxidative Protection, and Mitochondrial Dynamics Deterioration. J. Clin. Med. 8, 765. Doi: 10.3390/jcm8060765.

6) Kornicka-Garbowska K., Geburek F., Röcken M., Marycz K. 2019. Stem Cells in Equine Veterinary Practice—Current Trends, Risks, and Perspectives. J. Clin. Med. 8, 675. Doi: 10.3390/jcm8050675.

7) Kornicka-Garbowska K., Al Naem M., Röcken M., Zmiertka M., Marycz K. 2019. Osteochondritis Dissecans (OCD)-Derived Chondrocytes Display Increased Senescence, Oxidative Stress, Chaperone-Mediated Autophagy and, in Co-Culture with Adipose-Derived Stem Cells (ASCs), Enhanced Expression of MMP-13. J. Clin. Med. 8(3), 328. Doi: 10.3390/jcm8030328

8) Watras A., Wujczyk M., Röcken M., Kucharczyk K., Marycz K., Wiglusz R.J. 2019. Investigation of Pyrophosphates KYP2O7Co-Doped with Lanthanide Ions Useful for Theranostics. Nanomaterials, 9(11), 1597. Doi:10.3390/nano9111597.

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9) Bourebaba L., Bedjou F., Röcken M., Marycz K. 2019. Nortropane alkaloids as pharmacological chaperones in the rescue of equine adipose-derived mesenchymal stromal stem cells affected by metabolic syndrome through mitochondrial potentiation, endoplasmic reticulum stress mitigation and insulin resistance alleviation. Stem Cell Res Ther. 10, 178. Doi: 10.1186/s13287-019-1292-z.

10) Alicka M., Kornicka-Garbowska K., Kucharczyk K., Röcken M., Marycz K., 2019. Inhibition of the Low Molecular Weight Protein Tyrosine Phosphatase (LMPTP) as a Potential Therapeutic Strategy for Hepatic Progenitor Cells Lipotoxicity—Short Communication. Int. J. Mol. Sci. Doi: 10.3390/ijms20235873

11) Alicka M., Kornicka-Garbowska K., Kucharczyk K., Röcken M., Marycz K., 2020. Age-dependent impairment of adipose-derived stem cells isolated from horses. Stem Cell Res Ther. 11, Doi: 10.1186/s13287-019-1512-6

12) Bourebaba L., Kornicka-Garbowska K, Al Naem M., Röcken M., Łyczko J. & Marycz K. 2021. MSI-1436 improves EMS adipose derived progenitor stem cells in the course of adipogenic differentiation through modulation of ER stress, apoptosis, and oxidative stress. Stem Cell Res Ther. 12, Doi: 10.1186/s13287-020-02102-x

13) Golonka P., Kornicka-Garbowska K. & Marycz K. 2020.  SIRT1+ Adipose Derived Mesenchymal Stromal Stem Cells (ASCs) Suspended in Alginate Hydrogel for the Treatment of Subchondral Bone Cyst in Medial Femoral Condyle in the Horse. Clinical Report. Stem Cell Res Ther. 16, pages1328–1334, Doi: 10.1007/s12015-020-10025-6

14) Kowalczuk A., Bourebaba N., Kornicka-Garbowska K., Turlej E., Marycz K. & Bourebaba L., 2021. Hyoscyamus albus nortropane alkaloids reduce hyperglycemia and hyperinsulinemia induced in HepG2 cells through the regulation of SIRT1/NF-kB/JNK pathway, Cell Communication and Signaling, 19, Doi: 10.1186/s12964-021-00735-w

15) Zhao X., Liu Y.,Jia P., Cheng H., Wang Ch., Chen S., Huang H., Zhibo Han, Marycz K. 2021. Chitosan hydrogel-loaded MSC-derived extracellular vesicles promote skin rejuvenation by ameliorating the senescence of dermal fibroblasts, Stem Cell Res Ther., 12, Doi: 10.1186/s13287-021-02262-4

16) Sikora M., Śmieszek A., Marycz K., 2021. Bone marrow stromal cells (BMSCs CD45-/CD44+/CD73+/CD90+) isolated from osteoporotic mice SAM/P6 as a novel model for osteoporosis investigation, Doi: 10.1111/jcmm.16667

17) Marycz K., Pielok A., Kornicka-Garbowska K., 2021. Equine Hoof Stem Progenitor Cells (HPC) CD29 + /Nestin + /K15 + – a Novel Dermal/epidermal Stem Cell Population With a Potential Critical Role for Laminitis Treatment, Stem Cell Res Ther., Doi: 10.1007/s12015-021-10187-x

18) Kornicka-Garbowska K., Galuppo L., Marycz K., 2021, At the Dawn of Polytherapy for Laminitis Treatment-Novel Approach to an the Old Problems, Stem Cell Res Ther., Doi: 10.1007/s12015-021-10174-2

19) Kornicka-Garbowska K., Bourebaba L., Röcken M., Marycz K., 201.  Sex Hormone Binding Globulin (SHBG) Mitigates ER Stress in Hepatocytes In Vitro and Ex Vivo, Cells, 10 (4), Doi: 10.3390/cells10040755

20) Marycz K., Śmieszek A., Marcinkowska K., Sikora M., Turlej E., Sobierajska P., Patej A., Bienko A., Wiglusz R., 2021, Nanohydroxyapatite (nHAp) Doped with Iron Oxide Nanoparticles (IO), miR-21 and miR-124 Under Magnetic Field Conditions Modulates Osteoblast Viability, Reduces Inflammation and Inhibits the Growth of Osteoclast – A Novel Concept for Osteoporosis Treatment: Part 1, Int J Nanomedicine., 16, 3429–3456, Doi: 10.2147/IJN.S303412

21) Marycz K., Sobierajska P., Wiglusz R., Idczak R., Jean-Marie Nedelec, Fal A., Kornicka-Garbowska K., 2020, Fe3O4 Magnetic Nanoparticles Under Static Magnetic Field Improve Osteogenesis via RUNX-2 and Inhibit Osteoclastogenesis by the Induction of Apoptosis, Int J Nanomedicine., 15, 10127—10148, Doi: 10.2147/IJN.S256542

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Grants and projects

  1. OPUS 18 – “The role and therapeutic potential of sex hormone binding protein (SHBG) in insulin resistance, inflammation, lipotoxicity in adipose tissue progenitor cells and in adipocytes in mares with metabolic syndrome (EMS)” Project leader: prof. Krzysztof Marycz, Awarded amount: PLN 2,212,920
  2. OPUS 15 – “Inhibition of tyrosine phosphatase as a strategy of insulin sensitization by activating chaperone autophagy and suppressing the inflammatory reaction and cellular stress of the liver of horses with metabolic syndrome (EMS)” Project leader: prof. Krzysztof Marycz, Awarded amount: PLN 1,175,300
  3. HARMONIA 9 – “New, two-stage scaffolds based on calcium nanoapatite (nHAP) incorporated with iron nanoxides (Fe2O3 / Fe3O4) with the function of controlled miRNA release in a static magnetic field for the regeneration of bone fractures in osteoporotic patients”, Project leader: prof. Krzysztof Marycz, Awarded amount: PLN 1,194,200

CLINICAL RESEARCH

TRAINING

The International Institute of Translational Medicine offers a wide range of training courses dedicated to veterinarians, biologists, biotechnologists and students. We invite you to familiarize yourself with the upcoming trainings.

To receive the current training schedule, please contact:

info@mimt.com.pl | +48 505 469 278