CLINICAL VETERINARY

HORSES / INTERNAL DISEASES

INTERNAL DISEASES

Intensive research is currently ongoing at the MIMT, aimed at developing innovative therapy for pathological obesity, insulin resistance and the equine metabolic syndrome (EMS). Such therapy would be based on modern pharmacology and appropriate nutritional strategy.

lek. wet. Anna Cisło-Pakuluk (VS)

Small animals clinic director.

A graduate of the Faculty of Veterinary Medicine in Wrocław. She has been working with eye diseases of dogs, cats and horses since 2005. During her studies, she completed numerous apprenticeships and internships abroad, including a scholarship at the University of Budapest and the University of Ludwik Maximilian in Munich, in one of the best centers of veterinary ophthalmology in Europe, under the supervision of prof. H. Gerhards. After an internship at a horse hospital, she gained experience in the field of companion animal diseases at one of the largest clinics in Wrocław. Member of the European Society of Veterinary Ophthalmology, a longtime translator of ophthalmic publications for the Elsevier publishing house, author of many articles in the trade press. Regular participant in ESVO and ECVO conventions. She has completed a course in cataract surgery using the phacoemulsification method and cryosurgery. Lek.wet Anna Cisło-Pakuluk also completed the 1st degree course in ophthalmology in Luxembourg and the 2nd degree course in the field of ophthalmic surgery organized in Toulouse. Since 2016, she has additionally been involved in scientific work, aimed at applying the latest achievements of regenerative medicine in the treatment of retinal diseases.

The results of our research are the following scientific publications:

Bourebaba L, Bedjou F, Röcken M, Marycz K. Nortropane alkaloids as pharmacological chaperones in the rescue of equine adipose-derived mesenchymal stromal stem cells affected by metabolic syndrome through mitochondrial potentiation, endoplasmic reticulum stress mitigation and insulin resistance alleviation. Stem Cell Res Ther. 2019;10(1):178. Published 2019 Jun 18. doi:10.1186/s13287-019-1292-z

Bourebaba L, Marycz K. Pathophysiological Implication of Fetuin-A Glycoprotein in the Development of Metabolic Disorders: A Concise Review. J Clin Med. 2019;8(12):2033. Published 2019 Nov 21. doi:10.3390/jcm8122033

Bourebaba L, Michalak I, Baouche M, Kucharczyk K, Marycz K. Cladophora glomerata methanolic extract promotes chondrogenic gene expression and cartilage phenotype differentiation in equine adipose-derived mesenchymal stromal stem cells affected by metabolic syndrome. Stem Cell Res Ther. 2019;10(1):392. Published 2019 Dec 17. doi: 10.1186 /s13287-019-1499-z

Alicka M, Kornicka-Garbowska K, Roecken M, Marycz K. Inhibition of the Low Molecular Weight Protein Tyrosine Phosphatase (LMPTP) as a Potential Therapeutic Strategy for Hepatic Progenitor Cells Lipotoxicity-Short Communication. Int J Mol Sci. 2019;20(23):5873. Published 2019 Nov 22. doi:10.3390/ijms20235873

Marycz K., Szłapka-Kosarzewska J., Geburek F., Kornicka-Garbowska K. Systemic Administration of Rejuvenated Adipose-Derived Mesenchymal Stem Cells Improves Liver Metabolism in Equine Metabolic Syndrome (EMS)- New Approach in Veterinary Regenerative Medicine. Stem Cell Rev Rep 2019 Dec;15(6):842-850. doi: 10.1007/s12015-019-09913-3.

Bourebaba L, Michalak I, Baouche M, Kucharczyk K, Fal AM, Marycz K. Cladophora glomerata enriched by biosorption with Mn(II) ions alleviates lipopolysaccharide-induced osteomyelitis-like model in MC3T3-E1, and 4B12 osteoclastogenesis [published online ahead of print, 2020 Jun 4]. J Cell Mol Med. 2020;10.1111/jcmm.15294. doi:10.1111/jcmm.15294

Bourebaba L, Łyczko J, Alicka M, et al. Inhibition of Protein-tyrosine Phosphatase PTP1B and LMPTP Promotes Palmitate/Oleate-challenged HepG2 Cell Survival by Reducing Lipoapoptosis, Improving Mitochondrial Dynamics and Mitigating Oxidative and Endoplasmic Reticulum Stress. J Clin Med. 2020;9(5):E1294. Published 2020 May 1. doi:10.3390/jcm9051294