Research supported by several scientific publications

1) Al Naem M., Bourebaba L., Kucharczyk K., Röcken M., Marycz K. 2019. Therapeutic mesenchymal stromal stem cells: Isolation, characterization and role in equine regenerative medicine and metabolic disorders. Stem Cell Rep Rev. Doi: 10.1007/s12015-019-09932-0.

2) Marycz K., Kosarzewska-Szłapka J., Geburek F., Kornicka-Garbowska K. 2019. Systemic Administration of Rejuvenated Adipose-Derived Mesenchymal Stem Cells Improves Liver Metabolism in Equine Metabolic Syndrome (EMS)- New Approach in Veterinary Regenerative Medicine. Stem Cell Rev and Rep. Doi: 10.1007/s12015-019-09913-3

3) Alicka M., Kornicka-Garbowska K., Röcken M., Marycz K. 2019. Inhibition of the Low Molecular Weight Protein Tyrosine Phosphatase (LMPTP) as a Potential Therapeutic Strategy for Hepatic Progenitor Cells Lipotoxicity-Short Communication. Int. J. Mol. Sci. 20(23), 5873. Doi:10.3390/ijms20235873

4) Bourebaba L., Marycz K. 2019. Pathophysiological Implication of Fetuin-A Glycoprotein in the Development of Metabolic Disorders: A Concise Review. J. Clin. Med.8(12), 2033. Doi: 10.3390/jcm8122033

5) Alicka M., Major P., Wysocki M., Marycz K. 2019. Adipose-Derived Mesenchymal Stem Cells Isolated from Patients with Type 2 Diabetes Show Reduced “Stemness” through an Altered Secretome Profile, Impaired Anti-Oxidative Protection, and Mitochondrial Dynamics Deterioration. J. Clin. Med. 8, 765. Doi: 10.3390/jcm8060765.

6) Kornicka-Garbowska K., Geburek F., Röcken M., Marycz K. 2019. Stem Cells in Equine Veterinary Practice—Current Trends, Risks, and Perspectives. J. Clin. Med. 8, 675. Doi: 10.3390/jcm8050675.

7) Kornicka-Garbowska K., Al Naem M., Röcken M., Zmiertka M., Marycz K. 2019. Osteochondritis Dissecans (OCD)-Derived Chondrocytes Display Increased Senescence, Oxidative Stress, Chaperone-Mediated Autophagy and, in Co-Culture with Adipose-Derived Stem Cells (ASCs), Enhanced Expression of MMP-13. J. Clin. Med. 8(3), 328. Doi: 10.3390/jcm8030328

8) Watras A., Wujczyk M., Röcken M., Kucharczyk K., Marycz K., Wiglusz R.J. 2019. Investigation of Pyrophosphates KYP2O7Co-Doped with Lanthanide Ions Useful for Theranostics. Nanomaterials, 9(11), 1597. Doi:10.3390/nano9111597.

Ongoing Projects

Morris Animal Foundation (USA):

Our Institute acquired a funding from the prestigious Morris Animal Foundation (USA) which is a non-profit organization dedicated to advancing animal health and welfare. Currently, we are working on project related to Mitochondria in the diagnosis and treatment of canine glaucoma. Our team are looking for a novel biomarkers and developing a groundbreaking therapy for a blinding disease. The institute is carrying out a grant project with a renowned university from Israel, Koret University.

The National Center for Research and Development:

Due to the highly qualified scientific staff and innovative ideas, the institute successfully secures financing from NCBIR grants, the implementation of which contributes significantly to the development of RNA-related biotechnology. Moreover, The researches carried out at the institute have a high translational potential.

Innoglobo I

The Institute is implementing a project aimed at obtaining an innovative formula based on a carrier (polymeric/phospholipid or mixed) that will effectively protect miRNA molecules from the unfavorable stomach pH and allow delivery of miRNA molecules to the colon for stimulation of epithelial cells and gut microbiota. Confirmation of the clinical efficacy of the formulation will be achieved through alleviation of EMS symptoms at the systemic and molecular levels, including reduction in basal insulin and glucose levels, as well as decrease in pro-inflammatory protein levels and modulation of the insulin pathway.

Innoglobo II

We also acquired a funding in the second edition of Innoglobo. We are developing advanced technology for the industrial-scale production of a three-phase feed additive based on biofermented decaffeinated green coffee beans enriched with several active compounds and small non-coding RNA molecules, which will enhance the athletic performance of racehorses. The use of biofermented decaffeinated green coffee beans aims to obtain biomass with high antioxidant potential while the fermentation process will add products which stimulate the gut microbiota to activate AMP/ATP pathways and thus maintain the metabolic balance of muscle cells. The use of miRNA as an active factor at the post-transcriptional level for the first time will promote biogenesis and dynamics of mitochondria in muscle progenitor cells, leading to increased myogenesis and regeneration.